How is transcription regulated in stem cells? Pluripotent stem cells can potentially differentiate into any given cell type. They commonly exhibit mechanically softer nuclei [1], lack type-A lamins [2] and have a poorly defined cytoskeleton [3][4]. Embryonic stem cells are pluripotent in early organism [...]
How is DNA replicated? Cells must replicate their DNA before they can divide. This ensures that each daughter cell gets a copy of the genome, and therefore, successful inheritance of genetic traits. DNA replication is an essential process and the basic mechanism is conserved [...]
What is translation? Translation is a process that involves the synthesis of an amino acid chain from an mRNA blueprint. These polypeptide chains fold into functional proteins. Translation occurs outside the nucleus once nuclear processing of the pre-mRNA is complete and the mRNA molecules [...]
What are telomeres? Telomeres are short nucleotide sequences found at the end of linear chromosomes which protect the genetic information. In vertebrates, telomeres have the hexameric sequence TTAGGG. During DNA replication, the double stranded DNA is unwound and DNA polymerase synthesizes new strands. However, [...]
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One of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.