Assistant Professor, Department of Biological Sciences, Centre for Bioimaging Sciences (CBIS), Mechanobiology Institute, Singapore (MBI)
Endocytosis, Membrane traffic, Curvature, Actin cytoskeleton, Mechanotransduction
We are interested in elucidating the principles underlying the organization and dynamics of the subcellular membrane compartments. Specifically we are investigating how biological membranes are shaped through collective protein-lipid interactions and how geometry of the membrane compartment is coupled to cellular functions. We are using a combination of cell biological, biophysical and biochemical approaches to address these questions.
Dr. WU Min graduated from Peking University in China and received her bachelor degree in Chemistry. She did her graduate studies at Cornell University with Dr. Barbara Baird, where she initiated the use of patterned lipid bilayers as antigen-presenting platforms and studied immune cell activation and signal transduction. During her post-doctoral research in the laboratory of Dr. Pietro De Camilli at Yale School of Medicine, she focused on the molecular mechanisms of endocytosis. In 2011, she was awarded the NRF fellowship and will join CBIS/MBI in the fall.
Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations.
Wu, Min*; Wu, Xudong, De Camilli, Pietro*. (* co-corresponding authors). Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1339-44. doi: 10.1073/pnas.1221538110.
Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system.
Wu, Min; Huang, Bo; Graham, Morven; Raimondi, Andrea; Heuser, John E.; Zhuang, Xiaowei; De Camilli, Pietro., Nat Cell Biol. 2010 Sep;12(9):902-8. Highlighted in Science’s Editors’ Choice, selected by Faculty of 1000.
Differential targeting of secretory lysosomes and recycling endosomes in mast cells revealed by patterned antigen arrays.
Wu, Min; Baumgart, Tobias; Hammond, Stephanie; Holowka, David A.; Baird, Barbara A., J Cell Sci. 2007 Sep 1;120(Pt 17):3147-54. Selected by Faculty of 1000.
Visualization of plasma membrane compartmentalization with patterned lipid bilayers.
Wu, Min; Holowka, David A.; Craighead, Harold G.; Baird, Barbara A., Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13798-803.