Professor and Co-Director, Mechanobiology Institute, National University of Singapore
+65 6516 8908
Blk S1A, Level 2
Lee Wee Kheng Building
National University of Singapore
14 Science Drive 4
Leader, Mechanotransduction in Tissues
Professor, Department of Biological Sciences, National University of Singapore
Co-Director and Principal Investigator
Mechanobiology of cells and tissues, dynamics of nano-scale water, biomaging sciences
The main thrust of research in the last decade has been on the structure and mechanisms that generate force. In current research, the lab is studying two main problems: epithelial cell migration on 2D surfaces and mesenchymal/amoeboid cell migration in 3D matrices. We are studying how epithelial cells move in cell culture and in vivo and are characterizing the mechanical factors that control movement and the type of motility. Our interests in imaging arose from studies on the dynamics of actin bundles and cell adhesions. From its origin in the WI Keck Microscopy Facility and the WI-MIT BioImaging Center at MIT, the scale and scope of bioimaging has grown and moved in 2010 to the NUS Centre for BioImaging Sciences. With newly renovated labs opened in 2011, CBIS is devoted to development and application of state-of-art TEM and light microscopy methods to problems in molecular, cell, and tissue mechanobiology.
Recent research in the group share a common theme in dynamics: imaging of tissue formation and dynamics in developing Zebrafish embryos, imaging protein in room temperature water by real-time TEM, and super-resolution correlative light and electron microscopy.
Formerly a biology and bioengineering professor at the Massachusetts Institute of Technology (MIT), Prof Paul Matsudaira achieved significant discoveries on podosomes and polymer-based molecular motors for cell movement during his 24 years there. Appointed the Co-Director of MBI on June 2009, Prof Matsudaira presently heads the NUS Department of Biological Sciences.
PhD Dartmouth College
- Zheng JY, Tan HL, Matsudaira PT, and Choo A. Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis. Cell Death Differ. 2017;. [PMID: 28106884]
- . https://www.ncbi.nlm.nih.gov/pubmed/28007915
- Loh ND, Sen S, Bosman M, Tan SF, Zhong J, Nijhuis CA, Král P, Matsudaira P, and Mirsaidov U. Multistep nucleation of nanocrystals in aqueous solution. Nat Chem 2016; 9(1):77-82. [PMID: 27995918]
- Huang X, Huang S, Ong LC, Lim JC, Hurst RJM, Mushunje AT, Matsudaira PT, Han J, and Preiser PR. Differential Spleen Remodeling Associated with Different Levels of Parasite Virulence Controls Disease Outcome in Malaria Parasite Infections. mSphere 2015; 1(1). [PMID: 27303680]
- Shivashankar GV, Sheetz M, and Matsudaira P. Mechanobiology. Integr Biol (Camb) 2015; 7(10):1091-2. [PMID: 26404492]
- Luo Y, Singh VR, Bhattacharya D, Yew EYS, Tsai J, Yu S, Chen H, Wong J, Matsudaira P, So PTC, and Barbastathis G. Talbot holographic illumination nonscanning (THIN) fluorescence microscopy. Laser Photon Rev 2014; 8(5):L71-L75. [PMID: 25678936]
- Mirsaidov U, Mokkapati VRSS, Bhattacharya D, Andersen H, Bosman M, Özyilmaz B, and Matsudaira P. Scrolling graphene into nanofluidic channels. Lab Chip 2013; 13(15):2874-8. [PMID: 23702655]
- Mirsaidov UM, Zheng H, Bhattacharya D, Casana Y, and Matsudaira P. Direct observation of stick-slip movements of water nanodroplets induced by an electron beam. Proc. Natl. Acad. Sci. U.S.A. 2012; 109(19):7187-90. [PMID: 22517747]
- Mirsaidov UM, Zheng H, Casana Y, and Matsudaira P. Imaging protein structure in water at 2.7 nm resolution by transmission electron microscopy. Biophys. J. 2012; 102(4):L15-7. [PMID: 22385868]