About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
Linda J Kenney 2017-05-03T10:34:18+00:00
Linda J Kenney

Linda J KENNEY

Professor, Mechanobiology Institute, National University of Singapore

kenneyl@uic.edu
+65 6601 1285 ext 11285
Level 10 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Laboratory website
Bacterial Pathogenesis and Signal Transduction Lab (BPAST)

Research Program
Molecular Mechanics of Mechanotransduction

Affiliations
Professor of Microbiology & Immunology, Adjunct Professor of Bioengineering, University of Illinois-Chicago

Recent Research

Linda J Kenney

Principal Investigator

Research Areas

Signal transduction in Bacteria; Bacterial Pathogenesis; Mechanotransduction and osmotic signaling in E. coli; Mechanisms of anti-silencing of virulence genes in Salmonella

Research Interests

Our laboratory is interested in signal transduction and the regulation of gene expression in prokaryotes. In particular, we are studying the two-component regulatory system EnvZ/OmpR that regulates the expression of outer membrane proteins as well as many other genes. Our present work focuses on how OmpR activates genes required for systemic infection (located on Salmonella pathogenicity island 2) in Salmonella enterica.

The Kenney Lab’s research was recently featured in an article exploring the bacterial molecular switch between virulence or dormancy, Salmonella Lifestyle Choices. Members of her lab have discovered that the bacterial protein SsrB is the molecular switch for determining whether Salmonella infections become acute and virulent, or remain in a dormant carrier state.

The study is published in eLife (Desai et al., The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing, February 2, 2016, eLife 2016; 5: e10747, doi: 10.7554/eLife.10747). Read full article.

Biography

Dr Kenney is a Professor of Microbiology at the University of Illinois-Chicago. Her laboratory studies two-component systems in bacteria that control gene expression at a single cell and nanometer level.

Professor Linda J Kenney and Professor Michael Sheetz interviewed by the Washington Post at the April 2017 March for Science.

Education

PhD University of Pennsylvania

Recent Publications

  1. Lin M, Zhang G, Fahie M, Morgan LK, Chen M, Keiderling TA, Kenney LJ, and Liang J. Engineering a Novel Porin OmpGF via Strand Replacement From Computational Analysis of Sequence Motif. Biochim. Biophys. Acta 2017;. [PMID: 28341438]
  2. Ghosh M, Wang LC, Ramesh R, Morgan LK, Kenney LJ, and Anand GS. Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays. Biophys. J. 2017; 112(4):643-654. [PMID: 28256224]
  3. Desai SK, and Kenney LJ. To ∼P or Not to ∼P? Non-canonical Activation by Two-Component Response Regulators. Mol. Microbiol. 2016;. [PMID: 27656860]
  4. Desai SK, Winardhi RS, Periasamy S, Dykas MM, Jie Y, and Kenney LJ. The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing. Elife 2016; 5. [PMID: 26880544]
  5. Winardhi RS, Yan J, and Kenney LJ. H-NS Regulates Gene Expression and Compacts the Nucleoid: Insights from Single-Molecule Experiments. Biophys. J. 2015; 109(7):1321-9. [PMID: 26445432]
  6. Foo YH, Spahn C, Zhang H, Heilemann M, and Kenney LJ. Single cell super-resolution imaging of E. coli OmpR during environmental stress. Integr Biol (Camb) 2015; 7(10):1297-308. [PMID: 26156621]
  7. Foo YH, Gao Y, Zhang H, and Kenney LJ. Cytoplasmic sensing by the inner membrane histidine kinase EnvZ. Prog. Biophys. Mol. Biol. 2015; 118(3):119-29. [PMID: 25937465]
  8. Chakraborty S, Mizusaki H, and Kenney LJ. A FRET-based DNA biosensor tracks OmpR-dependent acidification of Salmonella during macrophage infection. PLoS Biol. 2015; 13(4):e1002116. [PMID: 25875623]
  9. Cheong FC, Wong CC, Gao Y, Nai MH, Cui Y, Park S, Kenney LJ, and Lim CT. Rapid, high-throughput tracking of bacterial motility in 3D via phase-contrast holographic video microscopy. Biophys. J. 2015; 108(5):1248-56. [PMID: 25762336]
  10. Lim CJ, Kenney LJ, and Yan J. Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties. Nucleic Acids Res. 2014; 42(13):8369-78. [PMID: 24990375]

Lab Members

Stuti K Desai

Apr 17th, 2017|Comments Off on Stuti K Desai

Senior Research Fellow, Kenney Group

Liu Xuyao Iris

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PhD Student, Kenney Group

Xu Lisheng

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PhD Student, Kenney Group

Yuki Yamanaka

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Research Fellow, Kenney Group

Parisa Zangoui Nejad Chahkootahi

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Research Fellow, Kenney Group

Liew Tze Fui Andrew

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Research Fellow, Kenney Group

Mrinal Dinesh Shah

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PhD Student, Kenney Group

Foo Yong Hwee

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Research Fellow, Kenney Group

Yunfeng Gao

Dec 1st, 2016|Comments Off on Yunfeng Gao

Research Associate, Kenney Group