About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
Jay Groves 2017-04-07T13:57:54+00:00
Jay GROVES

Jay GROVES

Co-Principal Investigator

jtgroves@lbl.gov
+01 510 666 3602
408A Stanley Hall
Berkeley College of Chemistry
Berkeley, CA 94720-1460

Curriculum Vitae

Laboratory website
Groves Lab

Research Program
Technology Innovation for Mechanobiology

Affiliations
Professor, Department of Chemistry and Howard Hughes Medical Institute Investigator, University of California, Berkeley, USA

Jay Groves

Co-Principal Investigator

Research Areas

Signal transduction; Cellular biophysics

Research Interests

Dr Groves has had a long-standing interest in the physical and biological aspects of cell membranes. His group combines aspects of cellular biophysics, physical chemistry, and materials science to study key aspects of signal transduction processes in cell membranes.

Biography

Dr Groves received his BS degree in Physics and Chemistry (summa cum laude) from Tufts University in 1992, followed by his Ph.D. in Biophysics from Stanford University in 1998. At Stanford, he worked with Professors Steven Boxer and Harden McConnell, and there developed the patterned supported membrane technology. In 1998 he went to Academia Sinica in Taipei, Taiwan as a Visiting Scholar, and then joined the Lawrence Berkeley National Laboratory as a Division Director’s Fellow in 1999. In 2001 he joined the faculty of the Chemistry Department at UC Berkeley, where he is currently an Associate Professor with tenure. In 2008 he became a Howard Hughes Medical Institute Investigator and in 2009 joined MBI. Dr Groves is best known for his introduction of the Spatial Mutation technology and its application to physical studies of cell biology.

Education

PhD Stanford University

Recent Publications

  1. Vafaei S, Tabaei SR, Biswas KH, Groves JT, and Cho N. Dynamic Cellular Interactions with Extracellular Matrix Triggered by Biomechanical Tuning of Low-Rigidity, Supported Lipid Membranes. Adv Healthc Mater 2017;. [PMID: 28371558]
  2. Biswas KH, Hartman KL, Zaidel-Bar R, and Groves JT. Sustained α-catenin Activation at E-cadherin Junctions in the Absence of Mechanical Force. Biophys. J. 2016; 111(5):1044-52. [PMID: 27602732]
  3. Biswas KH, and Groves JT. A Microbead Supported Membrane-Based Fluorescence Imaging Assay Reveals Intermembrane Receptor-Ligand Complex Dimension with Nanometer Precision. Langmuir 2016; 32(26):6775-80. [PMID: 27264296]
  4. Hanson JM, Gettel DL, Tabaei SR, Jackman J, Kim MC, Sasaki DY, Groves JT, Liedberg B, Cho N, and Parikh AN. Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic Peptide. Biophys. J. 2016; 110(1):176-87. [PMID: 26745420]
  5. Lee I, Kai H, Carlson L, Groves JT, and Hurley JH. Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly. Proc. Natl. Acad. Sci. U.S.A. 2015; 112(52):15892-7. [PMID: 26668364]
  6. Biswas KH, Hartman KL, Yu C, Harrison OJ, Song H, Smith AW, Huang WYC, Lin W, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R, and Groves JT. E-cadherin junction formation involves an active kinetic nucleation process. Proc. Natl. Acad. Sci. U.S.A. 2015; 112(35):10932-7. [PMID: 26290581]
  7. Iversen L, Tu H, Lin W, Christensen SM, Abel SM, Iwig J, Wu H, Gureasko J, Rhodes C, Petit RS, Hansen SD, Thill P, Yu C, Stamou D, Chakraborty AK, Kuriyan J, and Groves JT. Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics. Science 2014; 345(6192):50-4. [PMID: 24994643]
  8. Greene AC, Lord SJ, Tian A, Rhodes C, Kai H, and Groves JT. Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1. Biophys. J. 2014; 106(10):2196-205. [PMID: 24853748]