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When spacing matters

How ligand geometry affects matrix connections and cell spreading

A recent study led by Senior Research Fellow Rishita Changede uses custom 1D or 2D nanopatterns to demonstrate how the spacing between extracellular matrix fibers affect integrin clustering.

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Recent Featured Research

MBInsights Annual

MBInsights: Decoding the Living Machine

An annual summary of research at the Mechanobiology Institute, National University of Singapore

The annual is a synopsis showing the breadth of the research coming from the MBI. We are very proud of the fact that we have been able to build an institute with state-of-the-art capabilities in super-resolution microscopy and microfabrication. Our open lab environment and the energy of our students and postdocs have combined to take advantage of our experimental tools to answer important biological questions. Because we believe that these tools should be utilized to solve many more problems in the biomedical sciences, we invite you and your colleagues to join us in collaborative studies to solve those problems. Many different disciplines are needed since the problems need the tools of physicists, biologists, computational scientists, and engineers, working side-by-side to better understand how biological systems integrate mechanical cues and physical forces from the world around them.

Read more about MBInsights Annual 2017
See all editions of MBInsights Annual

Featured Video

photos-portraits-square-kenneyThe Linda J Kenney Lab

Kenney’s laboratory is interested in signal transduction and the regulation of gene expression in prokaryotes. They are studying the two-component regulatory system EnvZ/OmpR that regulates the expression of outer membrane proteins as well as many other genes. Their present work focuses on how OmpR activates genes required for systemic infection in Salmonella enterica. Learn more

Salmonella Lifestyle Choices

A bacterial molecular switch for infection or dormancy

Professor Linda Kenney describes a recent project from her lab on Salmonella pathogenesis. In this study, MBI Senior Research Fellow Dr Stuti Desai and colleagues discovered that the bacterial protein SsrB is the molecular switch for determining whether Salmonella infections become acute and virulent, or remain in a dormant carrier state.

Researchers from the Mechanobiology Institute (MBI), National University of Singapore have discovered that the bacterial protein SsrB is the molecular switch for determining whether Salmonella infections become acute and virulent, or remain in a dormant carrier state. This paper was published in eLife (Desai et al., The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing February 2, 2016, eLife 2016; 5: e10747, doi: 10.7554/eLife.10747).

Read the article on MBInsights

Awards

Awards and Honors

MBI acknowledges our celebrated principal investigators and researchers.

Prof. Hew Choy Leong honoured with the 2019 Outstanding Alumni Award for Academic Achievement

Prof. Hew Choy Leong, Emeritus Professor at NUS and Senior Advisor to the Mechanobiology Institute, was recently honoured with an Outstanding Alumni Award for Academic Achievement from Simon Fraser University, Canada.

By |Oct 7th, 2019|Categories: Awards, Main-1|Comments Off on Prof. Hew Choy Leong honoured with the 2019 Outstanding Alumni Award for Academic Achievement
News

News and Featured Events

Upcoming events, conferences, outreach and more at MBI.

2019 Frontiers in Mechanobiology

MBI is hosting a one day symposium, Frontiers in Mechanobiology, on July 15th, 2019. The symposium will feature nine speakers and a full schedule of talks of interest to those on the cutting edge of mechanobiology. The event is free and open to all interested, there is no registration required.

By |Jul 10th, 2019|Categories: Conference and Workshops|Comments Off on 2019 Frontiers in Mechanobiology
Visiting Scientists

Collaborators and Visiting Scientists

Visiting faculty, on-site guests and visitors.

MBI Publications

Latest Publications

  1. Lim SB, Tan SJ, Lim W, and Lim CT. Compendiums of cancer transcriptomes for machine learning applications. Sci Data 2019; 6(1):194. [PMID: 31594947]
  2. Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, and Sawada Y. Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. Sci Adv 2019; 5(9):eaau7802. [PMID: 31579816]
  3. Duclut C, Sarkar N, Prost J, and Jülicher F. Fluid pumping and active flexoelectricity can promote lumen nucleation in cell assemblies. Proc. Natl. Acad. Sci. U.S.A. 2019;. [PMID: 31492815]
  4. Khoo BL, Bouquerel C, Durai P, Anil S, Goh B, Wu B, Raman L, Mahendran R, Thamboo T, Chiong E, and Lim CT. Detection of Clinical Mesenchymal Cancer Cells from Bladder Wash Urine for Real-Time Detection and Prognosis. Cancers (Basel) 2019; 11(9). [PMID: 31480265]
  5. Changede R, Cai H, Wind SJ, and Sheetz MP. Integrin nanoclusters can bridge thin matrix fibres to form cell-matrix adhesions. Nat Mater 2019;. [PMID: 31477904]
  6. Wang Y, Barnett SFH, Le S, Guo Z, Zhong X, Kanchanawong P, and Yan J. Label-free Single-Molecule Quantification of Rapamyc