About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
Yu Hanry 2017-05-03T10:40:15+00:00
YU Hanry

YU Hanry

Professor, Mechanobiology Institute, National University of Singapore

+65 6516 3466
MD 9, #03-03; MD 1, #B1-03;
National University of Singapore
2 Medical Drive #04-01
Singapore 117597

Laboratory website
Laboratory of Cell and Tissue Engineering

Research Program
Technology Innovation for Mechanobiology

Professor, Department of Physiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore

Group Leader at the Institute of Bioengineering and Nanotechnology, A*STAR

Recent Research

Yu Hanry

Principal Investigator

Research Areas

Cell and Tissue Engineering Laboratory translates the latest biological and engineering knowledge into innovative technologies for diagnostics, therapeutics and drug testing applications in pharmaceutical and healthcare industry.

Research Interests

We adopt the latest industrial management models of teams to train future leaders of the R&D-based industry and academia. Our research expertise span from basic biological studies, biomaterials synthesis, to integrative engineering of biomedical devices that facilitate the translation of systems level understanding of biological functional processes into significant application solutions to help patients with liver diseases; and fuel biomedical industrial development in Asia. We acquire fundamental principles and technologies to quantitatively study and manipulate liver cell and tissue polarity and functions at meso-scale such that their global tissue structures and functions can be precision-engineered at mm-cm scales for applications.


Prof Yu is a Professor in the Department of Physiology, YLL School of Medicine, National University Health System; Principal Investigator at MBI and Group Leader at the Institute of Bioengineering and Nanotechnology, A*STAR. He was trained as a cell biologist but ventured into various other disciplines such as imaging, biomaterials, tissue engineering, drug testing, and computational biology of liver fibrosis. He takes pride in the interdisciplinary approach to research and graduate training; and he strives to build integrated teams to equip future graduates to readily adapt into both industrial and future academic settings.



Recent Publications

  1. Yan J, Yu Y, Kang JW, Tam ZY, Xu S, Fong ELS, Singh SP, Song Z, Tucker-Kellogg L, So PTC, and Yu H. Development of a classification model for non-alcoholic steatohepatitis (NASH) using confocal Raman micro-spectroscopy. J Biophotonics 2017;. [PMID: 28635128]
  2. Ong LJY, Chong LH, Jin L, Singh PK, Lee PS, Yu H, Ananthanarayanan A, Leo HL, and Toh Y. A pump-free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte-like cells. Biotechnol. Bioeng. 2017;. [PMID: 28542705]
  3. Narmada BC, Goh YT, Li H, Sinha S, Yu H, and Cheung C. Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals. Stem Cells Transl Med 2016; 6(3):851-863. [PMID: 28297582]
  4. Fong ELS, Toh TB, Yu H, and Chow EK. 3D Culture as a Clinically Relevant Model for Personalized Medicine. SLAS Technol 2017;:2472630317697251. [PMID: 28277923]
  5. Lou Y, Toh TC, Tee YH, and Yu H. 25-Hydroxyvitamin D3 induces osteogenic differentiation of human mesenchymal stem cells. Sci Rep 2017; 7:42816. [PMID: 28211493]
  6. Gupta K, Li Q, Fan JJ, Fong ELS, Song Z, Mo S, Tang H, Ng IC, Ng CW, Pawijit P, Zhuo S, Dong C, Low BC, Wee A, Dan YY, Kanchanawong P, So P, Viasnoff V, and Yu H. Actomyosin Contractility Drives Bile Regurgitation as an Early Response During Obstructive Cholestasis. J. Hepatol. 2017;. [PMID: 28189756]
  7. Choudhury Y, Toh YC, Xing J, Qu Y, Poh J, Huan L, Tan HS, Kanesvaran R, Yu H, and Tan M. Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Sci Rep 2017; 7:41238. [PMID: 28120901]
  8. Zhu L, Xia H, Wang Z, Fong ELS, Fan J, Tong WH, Seah YPD, Zhang W, Li Q, and Yu H. A vertical-flow bioreactor array compacts hepatocytes for enhanced polarity and functions. Lab Chip 2016; 16(20):3898-3908. [PMID: 27722715]
  9. Song Z, Shanmugam MK, Yu H, and Sethi G. Butein and Its Role in Chronic Diseases. Adv. Exp. Med. Biol. 928:419-433. [PMID: 27671826]
  10. Fong ELS, Harrington DA, Farach-Carson MC, and Yu H. Heralding a new paradigm in 3D tumor modeling. Biomaterials 2016; 108:197-213. [PMID: 27639438]

Lab Members

Kapish Gupta

Apr 13th, 2017|Comments Off on Kapish Gupta

PhD Student, Yu Group

Ng Chan Way

Apr 13th, 2017|Comments Off on Ng Chan Way

Research Assistant, Yu Group

Zhou Yan

Apr 13th, 2017|Comments Off on Zhou Yan

Research Associate, Yu Group

Ma Yukun

Apr 13th, 2017|Comments Off on Ma Yukun

Research Assistant, Yu Group