Professor, Department of Physiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore
Cell and Tissue Engineering Laboratory translates the latest biological and engineering knowledge into innovative technologies for diagnostics, therapeutics and drug testing applications in pharmaceutical and healthcare industry.
We adopt the latest industrial management models of teams to train future leaders of the R&D-based industry and academia. Our research expertise span from basic biological studies, biomaterials synthesis, to integrative engineering of biomedical devices that facilitate the translation of systems level understanding of biological functional processes into significant application solutions to help patients with liver diseases; and fuel biomedical industrial development in Asia. We acquire fundamental principles and technologies to quantitatively study and manipulate liver cell and tissue polarity and functions at meso-scale such that their global tissue structures and functions can be precision-engineered at mm-cm scales for applications.
Prof Yu is a Professor in the Department of Physiology, YLL School of Medicine, National University Health System; Principal Investigator at MBI and Group Leader at the Institute of Bioengineering and Nanotechnology, A*STAR. He was trained as a cell biologist but ventured into various other disciplines such as imaging, biomaterials, tissue engineering, drug testing, and computational biology of liver fibrosis. He takes pride in the interdisciplinary approach to research and graduate training; and he strives to build integrated teams to equip future graduates to readily adapt into both industrial and future academic settings.
Gupta K, Li Q, Fan JJ, Fong ELS, Song Z, Mo S, Tang H, Ng IC, Ng CW, Zhuo S, Dong C-Y, Low BC, Wee A, Dan YY, Kanchanawong P, So P, Viasnoff V, and Yu H. (2016) Actomyosin Contractility Drives Bile Regurgitation as an Early Homeostatic Response to Increased Biliary Pressure in Obstructive Cholestasis. Journal of Hepatology, accepted.
Ng IC, Pawijit P, Teo LY, Li HP, Lee SY, and Yu H. (2016) Kinectin-dependent endoplasmic reticulum transport supports focal complex maturation for chemotaxis in shallow gradients. Journal of Cell Science, 129(13): 2660-2672.
Li Q, Zhang Y, Pluchon P, Robens J, Herr K, Mercade M, Thiery JP, Yu H, and Viasnoff V. (2016) Environmental scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension. Nature Cell Biology, April 2016; 18:311-318.
Xing J, Toh Y-C, Xu S, and Yu H. (2015) A method for human teratogen detection by geometrically confined cell differentiation and migration. Scientific Reports, 12 May 2015; 5:
Xu S, Wang Y, Tai DCS, Wang S, Cheng CL, Peng Q, Yan J, Chen Y, Sun J, Liang X, Zhu Y, Rajapakse JC, Welsch R, So PTC, Wee A, Hou J, and Yu H. (2014) qFibrosis: A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients. Journal of Hepatology, August 2014; 61(2): 260-269.
Anene-Nzelu, C.G., Choudhury, D., Li, H., Fraiszudeen, A., Peh, K.Y., Toh, Y.-C., Ng, S.H., Leo, H.L., and Yu, H. (2013) Scalable cell alignment on optical media substrates. Biomaterials, July 2013; 34(21): 5078-5087.
Wang Y, Toh YC, Li Q, Nugraha B, Zheng B, Lu TB, Gao Y, Ng MMK, and Yu H. (2013) Mechanical compaction directly modulates the dynamics of bile canaliculi formation. Integrative Biology, 5(2): 390 – 401.
Choudhury D, van Noort D, Iliescu C, Zheng B, Poon KL, Korzh S, Korzh V, and Yu H. (2011) Fish and Chips: a microfluidic perfusion platform for monitoring zebrafish development. Lab on a Chip, 7 February 2012; 12(5): 892-900.
Xia L, Sakban RB, Qu Y, Hong X, Zhang W, Nugraha B, Tong WH, Ananthanarayanan A, Zheng B, Chau IYY, Jia R, McMillian M, Silva J, Dallas S, and Yu H. (2012) Tethered spheroids as an in vitro hepatocyte model for drug safety screening. Biomaterials, March 2012; 33(7): 2165-2176.