About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
Ronen Zaidel-Bar 2017-05-04T10:22:34+00:00
Michael SHEETZ

Ronen ZAIDEL-BAR

Assistant Professor, Mechanobiology Institute, National University of Singapore

biezbr@nus.edu.sg
+65 6601 1451 ext 11451
09-03-07 T-Lab
National University of Singapore
5A Engineering Drive 1
Singapore 117411

Laboratory website
Zaidel-Bar Cell Adhesion Lab

Research Program
The Cell-Matrix and Cell-Cell Mechanotransduction Group 

Cell-cell and cell-matrix adhesion, Regulation of actomyosin contractility and dynamics, C. elegans development, mechanics and molecular mechanisms of morphogenesis

Affiliations
Assistant Professor,  Department of Biomedical Engineering, National University of Singapore

Recent Research

Microscopic Muscles

How non-muscle cells find the strength to move

By | Feb 21st, 2017|Categories: Bershadsky Lab, Featured Research, Guo Z Research, Hu S Research, Science Features, Tee YH Research, Thiagarajan V Research, Zaidel-Bar Lab|Comments Off on Microscopic Muscles

Illuminating the Contacts

Using superresolution imagining to map adherens junction machinery

By | Feb 10th, 2017|Categories: Bertocchi Research, Featured Research, Hara Research, Kanchanawong Lab, Ladoux Lab, Ravasio Research, Science Features, Toyama Lab, Zaidel-Bar Lab|Comments Off on Illuminating the Contacts

Ronen Zaidel-Bar

Principal Investigator

Research Areas

Cell-cell and cell-matrix adhesion, Regulation of actomyosin contractility and dynamics, C. elegans development, mechanics and molecular mechanisms of morphogenesis

Research Interests

  1. How do specific cytoskeletal proteins contribute to the organization and function of cell adhesion and actomyosin structures?
  2. How are signals processed within the “adhesome” and “contractome” to arrive at the appropriate cytoskeletal arrangement for a given cell state?
  3. How do adhesion sites and the cytoskeleton sense and respond to external mechanical forces?

Biography

Dr Zaidel-Bar obtained his Ph.D. working with Prof Benny Geiger (Weizmann Institute of Science) on the role of force in regulating cell-matrix adhesions. Their work first focused on single proteins and evolved to encompass the entire adhesome network. In his Postdoctoral training with Prof Jeff Hardin (University of Wisconsin – Madison) Dr Zaidel-Bar switched from studying cells in culture to employing the genetic model organism C. elegans for the study of cell-cell adhesions during development. Dr Zaidel-Bar was attracted to Singapore by the opening of MBI and was awarded the Singapore National Research Foundation Fellowship for promising young investigators.

Education

PhD Weizmann Institute of Science

Recent Publications

  1. Ding WY, Ong HT, Hara Y, Wongsantichon J, Toyama Y, Robinson RC, Nédélec F, and Zaidel-Bar R. Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. J. Cell Biol. 2017;. [PMID: 28400443]
  2. Biswas KH, and Zaidel-Bar R. Early events in the assembly of E-cadherin adhesions. Exp. Cell Res. 2017;. [PMID: 28237244]
  3. Hu S, Dasbiswas K, Guo Z, Tee Y, Thiagarajan V, Hersen P, Chew T, Safran SA, Zaidel-Bar R, and Bershadsky AD. Long-range self-organization of cytoskeletal myosin II filament stacks. Nat. Cell Biol. 2017;. [PMID: 28114270]
  4. Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege R, and Kanchanawong P. Nanoscale architecture of cadherin-based cell adhesions. Nat. Cell Biol. 2016;. [PMID: 27992406]
  5. . https://www.ncbi.nlm.nih.gov/pubmed/27989674
  6. Biswas KH, Hartman KL, Zaidel-Bar R, and Groves JT. Sustained α-catenin Activation at E-cadherin Junctions in the Absence of Mechanical Force. Biophys. J. 2016; 111(5):1044-52. [PMID: 27602732]
  7. Rao MV, and Zaidel-Bar R. Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair. Mol. Biol. Cell 2016;. [PMID: 27440924]
  8. Budirahardja Y, Tan PY, Doan T, Weisdepp P, and Zaidel-Bar R. The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis. PLoS Genet. 2016; 12(5):e1006048. [PMID: 27176626]
  9. Erami Z, Timpson P, Yao W, Zaidel-Bar R, and Anderson KI. There are four dynamically and functionally distinct populations of E-cadherin in cell junctions. Biol Open 2015; 4(11):1481-9. [PMID: 26471767]
  10. Biswas KH, Hartman KL, Yu C, Harrison OJ, Song H, Smith AW, Huang WYC, Lin W, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R, and Groves JT. E-cadherin junction formation involves an active kinetic nucleation process. Proc. Natl. Acad. Sci. U.S.A. 2015; 112(35):10932-7. [PMID: 26290581]

Lab Members

Shinjini Ray

Jan 1st, 2017|Comments Off on Shinjini Ray

PhD Student, Zaidel-Bar Group

Krithi Sethi

Nov 1st, 2016|Comments Off on Krithi Sethi

Research Assistant, Zaidel-Bar Group

Agarwal Priti

Jul 1st, 2016|Comments Off on Agarwal Priti

Research Fellow, Zaidel-Bar Group

Regha Kakkad

Nov 15th, 2015|Comments Off on Regha Kakkad

Research Associate, Zaidel-Bar Group

Lim Jia Sheng Jason

Dec 1st, 2013|Comments Off on Lim Jia Sheng Jason

Research Assistant, Zaidel-Bar Group

Ding Wei Yung

Jan 1st, 2013|Comments Off on Ding Wei Yung

PhD Student, Zaidel-Bar Group

Anup Padmanabhan

Sep 10th, 2011|Comments Off on Anup Padmanabhan

Research Fellow, Zaidel-Bar Group