Ronen Zaidel-Bar

Principal Investigator, MBI

email: biezbr@nus.edu.sg
lab: Zaidel-Bar Cell Adhesion Lab

Assistant Professor,  Department of Biomedical Engineering, National University of Singapore

RESEARCH AREAS
Cell-cell and cell-matrix adhesion, C. elegans development, mechanics and molecular mechanisms of cadherin-mediated adhesion, interplay between cell-adhesion and actin dynamics.

RESEARCH INTERESTS
The assembly, ultrastructure, composition, and mechanosensory function of cadherin-mediated adhesions and the regulation of adherens junctions from single molecules to embryonic development.

BIOGRAPHY
Dr Zaidel-Bar obtained his Ph.D. working with Prof Benny Geiger (Weizmann Institute of Science) on the role of force in regulating cell-matrix adhesions. Their work first focused on single proteins and evolved to encompass the entire adhesome network. In his Postdoctoral training with Prof Jeff Hardin (University of Wisconsin – Madison) Dr Zaidel-Bar switched from studying cells in culture to employing the genetic model organism C. elegans for the study of cell-cell adhesions during development. Dr Zaidel-Bar was attracted to Singapore by the opening of MBI and was awarded the Singapore National Research Foundation Fellowship for promising young investigators.

PUBLICATIONS

Anup Padmanabhan, Hui Ting Ong, Ronen Zaidel-Bar. (2016) “Non-junctional E-Cadherin Clusters Regulate the Actomyosin Cortex in the C. elegans Zygote” Current Biology, doi: 10.1016/ j.cub.2016.10.032). Full article.

Murray P, and Zaidel-Bar R. (2014) “Premetazoan origins and evolution of the cadherin adhesome” Biology Open 3:1183-1195. doi: 10.1242/bio.20149761. Murray-2014

Guo Z, Neilson LJ, Hang Z, Murray P, Zanivan S, and Zaidel-Bar R. (2014) “E-cadherin adhesome complexity and robustness resolved by quantitative proteomics” Science Signaling 7(354), rs7. doi: 10.1126/scisignal.2005473. Guo2014

Tan P-Y and Zaidel-Bar R (2015) “Transient membrane localization of SPV-1 drives cyclical actomyosin contractions in the C. elegans spermatheca” Current Biology 25(2):141-51. doi: 10.1016/j.cub.2014.11.033. Tan2015

Wu Y, Kanchanawong P, and Zaidel-Bar R (2015) “Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions” Developmental Cell 32(2):139-54. doi: 10.1016/j.devcel.2014.12.003. Yao2015compressed

Budirahardja Y, Doan T, and Zaidel-Bar R “Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis” Plos Genetics, In Press.

Zaidel-Bar R (2013) “Job-splitting among integrins”. Nat Cell Biol. 2013 Jun;15(6):575-7. Zaidel-Bar2013(New&Views)

Vaman Rao M, Chu P-H, Hanh K, and Zaidel-Bar R (2013) “An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility”. Cytoskeleton DOI: 10.1002/cm.21115. Vaman Rao et al 2013 (Revised)

Zaidel-Bar R (2013) “Cadherin adhesome at a glance”. J Cell Sci 126, 373-378. ZaidelBar2013

Bertocchi C, Vaman Rao M, and Zaidel-Bar R. (2012) “Regulation of Adherens Junction Dynamics by Phosphorylation Switches,” J Signal Transduction, vol. 2012, Article ID 125295. Bertocchi2012

Cox-Paulson EA, Walck-ShannonE, Lynch AM, Yamashiro S, Zaidel-Bar R, Eno CC, Ono S, Hardin J. (2012) “Tropomodulin Protects a-catenin-dependent Junctional-Actin Networks Under Stress during Epithelial Morphogenesis”. Curr Biol 21;22(16):1500-5. Cox-Paulson2012

Geiger T, Zaidel-Bar R. (2012) “Opening the floodgates: proteomics and the integrin adhesome. Curr Opin Cell Biol 24(5):562-8.GeigerT2012

Neukomm LJ, Frei AP, Cabello J, Kinchen JM, Zaidel-Bar R, Ma Z, Haney LB, Hardin J, Ravichandran KS, Moreno S, Hengartner MO. (2011) “Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans”. Nat Cell Biol.13(1):79-86. Neukomm2011

Zaidel-Bar R., Joyce MJ., Lynch AM., Witte K, Audhya A, Hardin JD. (2010) “ The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis”. J Cell Biol 191(4):761-769. ZaidelBar2010c

Zaidel-Bar R., Geiger B. (2010) “The switchable integrin adhesome”. J Cell Sci 123(9):1385-8. ZaidelBar2010b

Zaidel-Bar R., Miller S., Broday L. (2010) “Molting-specific downregulation of C. elegans body-wall muscle attachment sites: The role of RNF-5 E3 ligase.”. Biochem Biophys Res Commun. ZaidelBar2010

Zaidel-Bar R. (2009) “Evolution of Complexity in the Integrin Adhesome.” J Cell Biol 186(3):317-21

Zaidel-Bar, R., Itzkovitz, S. and Geiger, B. (2009). “Protein networks in integrin-mediated adhesions”. In Systems Biomedicine: Concepts and Perspectives (ed. E.T. Liu and D.A. Lauffenburger), pp 139-152. Oxford: Academic Press. ZaidelBar2009b

Raz-Ben Aroush D., Zaidel-Bar R., Bershadsky AD., Wagner HD. (2008) “Temporal evolution of cell focal adhesions: experimental observations and shear stress profiles.” Soft Matter 4(12): 2410-2417. Dikla2008

Lockwood C., Zaidel-Bar R., Hardin JD. (2008) “The C. elegans Zonula Occludens ortholog ZOO-1 cooperates with the cadherin-catenin complex to recruit actin during epidermal morphogenesis” Curr Biol 18(17):1333-7. Lockwood2008

Zaidel-Bar, R., Itzkovitz S., Ma’ayan A., Iyengar R., Geiger B. (2007) “Functional atlas of the integrin adhesome.” Nat Cell Biol 9(8):858-67. ZaidelBar2007b

Zaidel-Bar R., Milo R., Kam Z., Geiger, B. (2007) “A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.” J Cell Sci 120(Pt1):137-48. ZaidelBar2007

Zaidel-Bar R., Kam Z., Geiger B. (2005). “Polarized down-regulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow ”. J Cell Sci 118(Pt17):3997-4007. ZaidelBar2005

Zaidel-Bar R., Cohen M., Addadi L., Geiger B. (2004). “Hierarchical assembly of cell-matrix adhesion complexes.” Biochem. Soc. Trans., 32(3). ZaidelBar2004

Zaidel-Bar R., C. Ballestrem, Z. Kam, B. Geiger (2003). “Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. ” J Cell Sci 116(Pt22):4605-13. ZaidelBar2003

Nabel-Rosen H., Volohonsky G., Reuveny A., Zaidel-Bar R., Volk T. (2002). “Two isoforms of the Drosophila RNA binding protein, how, act in opposing directions to regulate tendon cell differentiation.” Dev Cell 2(2):183-93. Nabel-Rosen2002