Ronen Zaidel-Bar

Principal Investigator, MBI

lab: Zaidel-Bar Cell Adhesion Lab

Assistant Professor,  Department of Biomedical Engineering, National University of Singapore

Cell-cell and cell-matrix adhesion, C. elegans development, mechanics and molecular mechanisms of cadherin-mediated adhesion, interplay between cell-adhesion and actin dynamics.

The assembly, ultrastructure, composition, and mechanosensory function of cadherin-mediated adhesions and the regulation of adherens junctions from single molecules to embryonic development.

Dr Zaidel-Bar obtained his Ph.D. working with Prof Benny Geiger (Weizmann Institute of Science) on the role of force in regulating cell-matrix adhesions. Their work first focused on single proteins and evolved to encompass the entire adhesome network. In his Postdoctoral training with Prof Jeff Hardin (University of Wisconsin – Madison) Dr Zaidel-Bar switched from studying cells in culture to employing the genetic model organism C. elegans for the study of cell-cell adhesions during development. Dr Zaidel-Bar was attracted to Singapore by the opening of MBI and was awarded the Singapore National Research Foundation Fellowship for promising young investigators.


Anup Padmanabhan, Hui Ting Ong, Ronen Zaidel-Bar. (2016) “Non-junctional E-Cadherin Clusters Regulate the Actomyosin Cortex in the C. elegans Zygote” Current Biology, doi: 10.1016/ j.cub.2016.10.032). Full article.

Murray P, and Zaidel-Bar R. (2014) “Premetazoan origins and evolution of the cadherin adhesome” Biology Open 3:1183-1195. doi: 10.1242/bio.20149761. Murray-2014

Guo Z, Neilson LJ, Hang Z, Murray P, Zanivan S, and Zaidel-Bar R. (2014) “E-cadherin adhesome complexity and robustness resolved by quantitative proteomics” Science Signaling 7(354), rs7. doi: 10.1126/scisignal.2005473. Guo2014

Tan P-Y and Zaidel-Bar R (2015) “Transient membrane localization of SPV-1 drives cyclical actomyosin contractions in the C. elegans spermatheca” Current Biology 25(2):141-51. doi: 10.1016/j.cub.2014.11.033. Tan2015

Wu Y, Kanchanawong P, and Zaidel-Bar R (2015) “Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions” Developmental Cell 32(2):139-54. doi: 10.1016/j.devcel.2014.12.003. Yao2015compressed

Budirahardja Y, Doan T, and Zaidel-Bar R “Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis” Plos Genetics, In Press.

Zaidel-Bar R (2013) “Job-splitting among integrins”. Nat Cell Biol. 2013 Jun;15(6):575-7. Zaidel-Bar2013(New&Views)

Vaman Rao M, Chu P-H, Hanh K, and Zaidel-Bar R (2013) “An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility”. Cytoskeleton DOI: 10.1002/cm.21115. Vaman Rao et al 2013 (Revised)

Zaidel-Bar R (2013) “Cadherin adhesome at a glance”. J Cell Sci 126, 373-378. ZaidelBar2013

Bertocchi C, Vaman Rao M, and Zaidel-Bar R. (2012) “Regulation of Adherens Junction Dynamics by Phosphorylation Switches,” J Signal Transduction, vol. 2012, Article ID 125295. Bertocchi2012

Cox-Paulson EA, Walck-ShannonE, Lynch AM, Yamashiro S, Zaidel-Bar R, Eno CC, Ono S, Hardin J. (2012) “Tropomodulin Protects a-catenin-dependent Junctional-Actin Networks Under Stress during Epithelial Morphogenesis”. Curr Biol 21;22(16):1500-5. Cox-Paulson2012

Geiger T, Zaidel-Bar R. (2012) “Opening the floodgates: proteomics and the integrin adhesome. Curr Opin Cell Biol 24(5):562-8.GeigerT2012

Neukomm LJ, Frei AP, Cabello J, Kinchen JM, Zaidel-Bar R, Ma Z, Haney LB, Hardin J, Ravichandran KS, Moreno S, Hengartner MO. (2011) “Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans”. Nat Cell Biol.13(1):79-86. Neukomm2011

Zaidel-Bar R., Joyce MJ., Lynch AM., Witte K, Audhya A, Hardin JD. (2010) “ The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis”. J Cell Biol 191(4):761-769. ZaidelBar2010c

Zaidel-Bar R., Geiger B. (2010) “The switchable integrin adhesome”. J Cell Sci 123(9):1385-8. ZaidelBar2010b

Zaidel-Bar R., Miller S., Broday L. (2010) “Molting-specific downregulation of C. elegans body-wall muscle attachment sites: The role of RNF-5 E3 ligase.”. Biochem Biophys Res Commun. ZaidelBar2010

Zaidel-Bar R. (2009) “Evolution of Complexity in the Integrin Adhesome.” J Cell Biol 186(3):317-21

Zaidel-Bar, R., Itzkovitz, S. and Geiger, B. (2009). “Protein networks in integrin-mediated adhesions”. In Systems Biomedicine: Concepts and Perspectives (ed. E.T. Liu and D.A. Lauffenburger), pp 139-152. Oxford: Academic Press. ZaidelBar2009b

Raz-Ben Aroush D., Zaidel-Bar R., Bershadsky AD., Wagner HD. (2008) “Temporal evolution of cell focal adhesions: experimental observations and shear stress profiles.” Soft Matter 4(12): 2410-2417. Dikla2008

Lockwood C., Zaidel-Bar R., Hardin JD. (2008) “The C. elegans Zonula Occludens ortholog ZOO-1 cooperates with the cadherin-catenin complex to recruit actin during epidermal morphogenesis” Curr Biol 18(17):1333-7. Lockwood2008

Zaidel-Bar, R., Itzkovitz S., Ma’ayan A., Iyengar R., Geiger B. (2007) “Functional atlas of the integrin adhesome.” Nat Cell Biol 9(8):858-67. ZaidelBar2007b

Zaidel-Bar R., Milo R., Kam Z., Geiger, B. (2007) “A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.” J Cell Sci 120(Pt1):137-48. ZaidelBar2007

Zaidel-Bar R., Kam Z., Geiger B. (2005). “Polarized down-regulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow ”. J Cell Sci 118(Pt17):3997-4007. ZaidelBar2005

Zaidel-Bar R., Cohen M., Addadi L., Geiger B. (2004). “Hierarchical assembly of cell-matrix adhesion complexes.” Biochem. Soc. Trans., 32(3). ZaidelBar2004

Zaidel-Bar R., C. Ballestrem, Z. Kam, B. Geiger (2003). “Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. ” J Cell Sci 116(Pt22):4605-13. ZaidelBar2003

Nabel-Rosen H., Volohonsky G., Reuveny A., Zaidel-Bar R., Volk T. (2002). “Two isoforms of the Drosophila RNA binding protein, how, act in opposing directions to regulate tendon cell differentiation.” Dev Cell 2(2):183-93. Nabel-Rosen2002