NUS Centre for BioImaging Sciences (CBIS)

Founded by faculty from Biological Sciences, Chemistry, and Physics, the Centre for BioImaging Sciences’s (CBIS) research is focused on the science and application of biological imaging by light and electron microscopy and the development of computational and microscopy-based methods and technologies.

CBIS microscope

CBIS’s experimental floor is organized around five specially designed optical rooms housing custom designed and built microscopes, five core equipment rooms, a very large tissue culture room, and a central space containing wet benches for 60 researchers.

An interdisciplinary Approach

With an interdisciplinary emphasis on the mechanism of biological processes at the molecular, cell, and tissue levels, CBIS complements the development of advanced light microscopy technologies by the Optical Bioengineering Laboratory in the NUS Department of Biomedical Engineering, the medical imaging research and applications in the Singapore Bioimaging Consortium, and the advanced confocal and super-resolution microscopes of the Mechanobiology Institute, Singapore.

CBIS titan

The Titan Krios transmission electron microscope (FEI, Netherlands) is state-of-the-art equipment for visualizing native structures of biological samples to atomic resolution.

With the installation of the FEI Titan Krios in May 2010, the Cryoelectron Microscope Facility joins a select group of state-of-art, high-end cryoelectron microscopy facilities in the world.

By minimizing EMI, reducing relative humidity to 30%, and together with the exceptionally quiet acoustic and low mechanical vibration levels, all microscopes in the facility are able to easily reach designed performance specifications. From this perspective both FEI and JEOL inform us that the Facility is among the best sites where their TEMs have been installed world-wide.

In addition to the four TEMs, the 30% RH rooms also contain instruments for cryofreezing of samples and cryosectioning.  A separate room in S1A houses a high-pressure freezing instrument for ultra-fast freezing of thick samples. The instruments are supported and maintained by excellent technical staff trained in biological sample preparation and imaging. The facility is the most advanced TEM facility in Singapore. Find out more about the Cryoelectron Microscopy Facility.

A Message from the Centre’s Director

“At CBIS, we have the ability to find new answers as well as ask new questions that enhance our understanding of the most complex issues in biology. We invite you to explore the Centre for BioImaging Sciences, and to join us in applying our tools, resources, and expertise to the microscopic mysteries that await discovery.” Read a message from Paul Matsudaira, Director, CBIS.