To ∼P or Not to ∼P? Non-canonical Activation by Two-Component Response Regulators. Molecular Microbiology, 2016.

By Stuti K Desai1, Linda J Kenney2,3,4.

Molecular Microbiology. September 2016. doi: 10.1111/mmi.13532. Epub ahead of print.

Abstract

Bacteria sense and respond to their environment through the use of two-component regulatory systems. The ability to adapt to a wide range of environmental stresses is directly related to the number of two-component systems an organism possesses. Recent advances in this area have identified numerous variations on the archetype systems that employ a sensor kinase and a response regulator. It is now evident that many orphan regulators that lack cognate kinases do not rely on phosphorylation for activation and new roles for unphosphorylated response regulators have been identified. The significance of recent findings and suggestions for further research are discussed.

 

1Mechanobiology Institute, 5A Engineering Drive 1, National University of Singapore, Singapore.
2Mechanobiology Institute, 5A Engineering Drive 1, National University of Singapore, Singapore.
3Jesse Brown Veteran’s Administration Medical Center, Chicago, IL, USA.
4Department of Microbiology & Immunology, University of Illinois-Chicago, Chicago, IL, USA.