LIM Chwee Teck
Professor, Mechanobiology Institute, National University of Singapore
E3, #05-10, 9 Engineering Drive 1
Dept of Biomedical Engineering
National University of Singapore
Leader, Technology Innovation for Mechanobiology Group
NUSS Professor, National University of Singapore
A question of life and death
Making sure to expel an unwanted cell
MBI Scientists reveal the effects of ECM topography on the poliferation of normal and cancer cells
A tool for point-of-care cancer diagnostics and treatment
Culturing tumor cells to predict treatment outcome
A cellular tug-of-war mechanically drives gap closure
Lim Chwee Teck
Collective cell migration; Human disease mechanobiology; Microfluidic technologies for disease detection and diagnosis, Flexible wearable technologies for healthcare applications
We aim to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases and development of mechanobiologically inspired platforms in microfluidics, tunable nanomaterials and flexible wearable devices to better detect, diagnose and treat diseases as well as enable precision medicine.
Another major research interest is collective cell migration which is central to the development and maintenance of multicellular organisms and requires orchestrated movement of cells in specific directions to specific locations and within geometrical constraints. Thus, understanding the mechanisms by which cells collective migrate may potentially lead to the development of therapeutic strategies for diseases such as cancer or for tissue repair. Here, we seek to understand how mechanical cues such as spatial organisation of ECM proteins or geometrical constraints can regulate and coordinate collective migration of cells as well as force transmission across the cell sheet.
Professor Lim is a NUSS Professor at the Department of Biomedical Engineering, a Principal Investigator at the Mechanobiology Institute as well as a Faculty Fellow of the Singapore-MIT Alliance for Research & Technology. He is founding member of the Department of Biomedical Engineering, the university’s Nanoscience and Nanotechnology Initiative as well as the university’s Centre for Advanced 2D Materials. Prof Lim’s research interest are interdisciplinary and they include the mechanobiology of human diseases such as malaria and cancer, development of microfluidic technologies for disease detection, diagnosis and precision therapy and flexible wearable technologies for healthcare applications.
He has authored more than 330 peer-reviewed journal papers, 28 book chapters and delivered more than 310 plenary/keynote/invited talks. He is an elected Fellow of the American Institute for Medical and Biological Engineering, International Academy of Medical and Biological Engineering as well as the Academy of Engineering, Singapore. He is also an elected member of the World Council of Biomechanics. He currently sits on the editorial boards of more than 14 international journals. Prof Lim has co-founded one incubator and five startups which are commercializing technologies developed in his lab.
He and his team have garnered more than 70 research awards and honors including Winner of IDTechEx Launchpad 2017, International Precision Medicine Conference Prize 2017, ASEAN Outstanding Engineering Achievement Award and Asian Scientists 100 in 2016, Vladimir K. Zworykin Award in 2015, University’s Outstanding Researcher Award and Outstanding Innovator Award in 2014, the Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold) in 2012, President’s Technology Award in 2011 and the IES Prestigious Engineering Achievement Award in 2010 among others. His research was cited by the MIT Technology Review magazine as one of the top ten emerging technologies of 2006 that will “have a significant impact on business, medicine or culture.”
BEng in Mechanical Engineering (with First Class Honours), National University of Singapore
PhD University of Cambridge, UK
- Saw, T B et al, Topological defects in epithelia govern cell death and extrusion, Nature, 544, 212-216, 2017. [PMID: 28406198]
- Warkiani, M E, et al, Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics, Nature Protocols, 14, 1, 128-37, 2016. [PMID: 26678083]
- Khoo, B L et al, Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment. Science Advances, 2, 7, e1600274, 2016. [PMID: 27453941]
- Gupta, M et al, Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing, Nature Communications, 6, 7525, 2015. [PMID: 26109233]
- Vedula, S R K et al, Mechanics of epithelial closure over non-adherent environments, Nature Communications, 6, 6111, 2015. [PMID: 25608921]
- Lee, W C et al, Multivariate biophysical markers predictive of mesenchymal stromal cell multi potency, PNAS, 111(42):E4409-18, 2014. [PMID: 25298531]
- Yao, M et al, Force-dependent conformational switch of a-catenin controls vinculin binding, Nature Communications, 5, 4525, 2014. [PMID: 25077739]
- Vedula, S R K et al, Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 13, 87-96, 2014. [PMID: 24292420]
- Thiery, J P, C T Lim, Tumor dissemination: An EMT affair, Cancer Cell, 23, 3, 272-273, 2013. [PMID: 23518345]
- Vedula, S R K et al, Emerging modes of collective cell migration induced by geometrical constraints, PNAS, 109, 32, 12974-12979, 2012. [PMID: 22814373]