About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
Lim Chwee Teck 2017-05-17T15:23:39+00:00
LIM Chwee Teck

LIM Chwee Teck

Professor, Mechanobiology Institute, National University of Singapore

ctlim@nus.edu.sg
+65 65167801
E3, #05-10, 9 Engineering Drive 1
Dept of Biomedical Engineering
National University of Singapore
Singapore 117581

Curriculum Vitae

Laboratory website
MechanoBioEngineering Laboratory

Research Program
Leader, Technology Innovation for Mechanobiology Group

Affiliations
NUSS Professor, National University of Singapore

Deputy Head, Department of Biomedical Engineering, National University of Singapore

Group Head, Centre for Advanced 2D Materials, National University of Singapore

Recent Research

Cell Extrusion Mechanisms

Making sure to expel an unwanted cell

By | Oct 20th, 2016|Categories: Featured Research, Ladoux Lab, Le AP Research, Lim CT Lab, Saw TB Research, Science Features, Shagirov M Research, Toyama Lab, Yow I Research|Comments Off on Cell Extrusion Mechanisms

Lim Chwee Teck

Principal Investigator

Research Areas

Collective cell migration; Human disease mechanobiology; Microfluidic technologies for disease detection and diagnosis, Flexible wearable technologies for healthcare applications

Research Interests

We aim to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases and development of mechanobiologically inspired platforms in microfluidics, tunable nanomaterials and flexible wearable devices to better detect, diagnose and treat diseases as well as enable precision medicine.

Another major research interest is collective cell migration which is central to the development and maintenance of multicellular organisms and requires orchestrated movement of cells in specific directions to specific locations and within geometrical constraints. Thus, understanding the mechanisms by which cells collective migrate may potentially lead to the development of therapeutic strategies for diseases such as cancer or for tissue repair. Here, we seek to understand how mechanical cues such as spatial organisation of ECM proteins or geometrical constraints can regulate and coordinate collective migration of cells as well as force transmission across the cell sheet.

Biography

Professor Lim is a NUSS Professor at the Department of Biomedical Engineering, a Principal Investigator at the Mechanobiology Institute as well as a Faculty Fellow of the Singapore-MIT Alliance for Research & Technology. He is founding member of the Department of Biomedical Engineering, the university’s Nanoscience and Nanotechnology Initiative as well as the university’s Centre for Advanced 2D Materials. Prof Lim’s research interest are interdisciplinary and they include the mechanobiology of human diseases such as malaria and cancer, development of microfluidic technologies for disease detection, diagnosis and precision therapy and flexible wearable technologies for healthcare applications.

He has authored more than 330 peer-reviewed journal papers, 28 book chapters and delivered more than 310 plenary/keynote/invited talks. He is an elected Fellow of the American Institute for Medical and Biological Engineering, International Academy of Medical and Biological Engineering as well as the Academy of Engineering, Singapore. He is also an elected member of the World Council of Biomechanics. He currently sits on the editorial boards of more than 14 international journals. Prof Lim has co-founded one incubator and five startups which are commercializing technologies developed in his lab.

He and his team have garnered more than 70 research awards and honors including Winner of IDTechEx Launchpad 2017, International Precision Medicine Conference Prize 2017, ASEAN Outstanding Engineering Achievement Award and Asian Scientists 100 in 2016, Vladimir K. Zworykin Award in 2015, University’s Outstanding Researcher Award and Outstanding Innovator Award in 2014, the Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold) in 2012, President’s Technology Award in 2011 and the IES Prestigious Engineering Achievement Award in 2010 among others. His research was cited by the MIT Technology Review magazine as one of the top ten emerging technologies of 2006 that will “have a significant impact on business, medicine or culture.”

Education

BEng in Mechanical Engineering (with First Class Honours), National University of Singapore

PhD University of Cambridge, UK

Selected Publications

  1. Saw, T B et al, Topological defects in epithelia govern cell death and extrusion, Nature, 544, 212-216, 2017. [PMID: 28406198]
  2. Warkiani, M E, et al, Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics, Nature Protocols, 14, 1, 128-37, 2016. [PMID: 26678083]
  3. Khoo, B L et al, Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment. Science Advances, 2, 7, e1600274, 2016. [PMID: 27453941]
  4. Gupta, M et al, Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing, Nature Communications, 6, 7525, 2015. [PMID: 26109233]
  5. Vedula, S R K et al, Mechanics of epithelial closure over non-adherent environments, Nature Communications, 6, 6111, 2015. [PMID: 25608921]
  6. Lee, W C et al, Multivariate biophysical markers predictive of mesenchymal stromal cell multi potency, PNAS, 111(42):E4409-18, 2014. [PMID: 25298531]
  7. Yao, M et al, Force-dependent conformational switch of a-catenin controls vinculin binding, Nature Communications, 5, 4525, 2014. [PMID: 25077739]
  8. Vedula, S R K et al, Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 13, 87-96, 2014. [PMID: 24292420]
  9. Thiery, J P, C T Lim, Tumor dissemination: An EMT affair, Cancer Cell, 23, 3, 272-273, 2013. [PMID: 23518345]
  10. Vedula, S R K et al, Emerging modes of collective cell migration induced by geometrical constraints, PNAS, 109, 32, 12974-12979, 2012. [PMID: 22814373]

Recent Publications

  1. Li BL, Setyawati MI, Chen L, Xie J, Ariga K, Lim C, Garaj S, and Leong DT. Directing Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery. ACS Appl Mater Interfaces 2017;. [PMID: 28452468]
  2. Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, Toyama Y, Marcq P, Lim CT, Yeomans JM, and Ladoux B. Topological defects in epithelia govern cell death and extrusion. Nature 2017; 544(7649):212-216. [PMID: 28406198]
  3. Syn NL, Wang L, Chow EK, Lim CT, and Goh B. Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges. Trends Biotechnol. 2017;. [PMID: 28365132]
  4. Chakraborty S, Njah K, Pobbati AV, Lim YB, Raju A, Lakshmanan M, Tergaonkar V, Lim CT, and Hong W. Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway. Cell Rep 2017; 18(10):2464-2479. [PMID: 28273460]
  5. Singh H, Madnani K, Lim YB, Cao J, Preiser PR, and Lim CT. Expression dynamics & physiologically relevant functional study of STEVOR in asexual stages of Plasmodium falciparum infection. Cell. Microbiol. 2016;. [PMID: 28030753]
  6. Hirata H, Gupta M, Vedula SRK, Lim CT, Ladoux B, and Sokabe M. Quantifying Tensile Force and ERK Phosphorylation on Actin Stress Fibers. Methods Mol. Biol. 2017; 1487:223-234. [PMID: 27924570]
  7. Kenry , Geldert A, Lai Z, Huang Y, Yu P, Tan C, Liu Z, Zhang H, and Lim CT. Single-Layer Ternary Chalcogenide Nanosheet as a Fluorescence-Based "Capture-Release" Biomolecular Nanosensor. Small 2016;. [PMID: 27860209]
  8. Jing T, Lai Z, Wu L, Han J, Lim CT, and Chen C. Single Cell Analysis of Leukocyte Protease Activity Using Integrated Continuous-Flow Microfluidics. Anal. Chem. 2016; 88(23):11750-11757. [PMID: 27797505]
  9. Yeo JC, Kenry , and Lim CT. Emergence of microfluidic wearable technologies. Lab Chip 2016;. [PMID: 27713996]
  10. Kocgozlu L, Saw TB, Le AP, Yow I, Shagirov M, Wong E, Mège R, Lim CT, Toyama Y, and Ladoux B. Epithelial Cell Packing Induces Distinct Modes of Cell Extrusions. Curr. Biol. 2016;. [PMID: 27746027]

Lab Members

Jiang Kuan

May 24th, 2017|Comments Off on Jiang Kuan

PhD Student, CT Lim Group

Saw Thuan Beng

Apr 25th, 2017|Comments Off on Saw Thuan Beng

PhD Student, Lim Group, Ladoux Group

Le Anh Phuong

Apr 25th, 2017|Comments Off on Le Anh Phuong

PhD Student, Ladoux Group, Lim Group

Nai Mui Hoon Brenda

Apr 13th, 2017|Comments Off on Nai Mui Hoon Brenda

Research Associate, Lim Group

Supatra Tharinee Marsh

Apr 13th, 2017|Comments Off on Supatra Tharinee Marsh

Research Fellow, Lim Group

Sarvesh Abhay Sukhatme

Apr 13th, 2017|Comments Off on Sarvesh Abhay Sukhatme

Research Assistant, Lim Group

Shreyansh Jain

Apr 13th, 2017|Comments Off on Shreyansh Jain

PhD Student, Lim Group, Ladoux Group

Parthiv Kant Chaudhuri

Apr 13th, 2017|Comments Off on Parthiv Kant Chaudhuri

PhD Student, Lim Group