Assistant Professor, School of Biological Sciences, Nanyang Technological University
Cell signalling; Regulation of actin cytoskeleton; Rho GTPases, their effectors and regulators
Our laboratory is interested in the signal transduction events involving small GTPases of the Rho family, their regulators and effectors. These proteins play key roles in transducing extracellular stimuli into distinct responses including cell shape changes, cell motility, adhesion, cell division and phagocytosis. The emphasis of our current research is on the kinase PAK, its interacting protein PIX and a family of serine/ threonine phosphataes of the PP2C family, POPXs.
Dr Koh did her undergraduate studies at the Department of Chemistry at the National University of Singapore. After completing her Ph.D. with Sydney Brenner at the University of Cambridge, she returned to Singapore to work on Fugu genomics at the Institute of Molecular and Cell Biology. She later moved to Louis Lim’s laboratory at the same institute to study small GTPases-mediated cell signaling. In 2004, Dr Koh started her own laboratory at the School of Biological Sciences, Nanyang Technological University. Dr Koh is also a Principal Investigator at MBI.
Zhang S, Guo T, Chan H, Sze SK, and Koh CG*. 2013. An integrative transcriptome and proteome study to identify the signaling network regulated by POPX2 phosphatase. Journal of Proteome Research, 12: 2525-2536.
Lee YP, Wong CH, Chan KS, Lai SK, Koh CG* and Li HY*. 2012. In vivo FRET revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase. PLoS One. 7: e45836. *corresponding authors.
Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT and Koh CG*. 2012. TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation. Journal of Cell Science, 125: 1579-1590.
Zeng Y, Lai T, Koh CG, LeDuc PR, and Chiam KH. 2011. Investigating circular dorsal ruffles through varying substrate stiff ness and mathematical modeling. Biophysical Journal. 101:2121-2130.
Singh P, Gan CS, Guo T, Phang H-Q(s), Sze SK and Koh CG*. 2011. Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis. Proteomics, 11:2891-2900.
Susila, A, Chan H, Loh AXW, HQ Phang, ET Wong, Tergaonkar V and Koh CG*. 2010. POPX2, the negative regulator of the kinase PAK, regulates cancer cell motility and invasiveness. Cell Cycle, 9: 179-187.
Wong CH, Chan H, Ho CY, Lai SK, Chan KS, Koh CG* & Hoi-Yeung Li*. 2009. Apoptotic histone modification inhibits nuclear transport by regulating RCC1. Nature Cell Biology, 11: 36-45. *corresponding authors.
Xie Y, Tan E-J, Wee S, Manser E, Lim L and Koh CG*. 2008. Functional Interactions between POPX2 phosphatase and mDia modulate RhoA pathways. Journal of Cell Science, 121:514-521.