MBM & Manchester symposium 2013


About   |   Program   |   Registration   |   Speakers


The Manchester-MBI Joint Symposium is a joint effort involving scientists from Manchester University, primarily from the Wellcome Trust Centre for Cell-Matrix Research, and the Mechanobiology Institute, Singapore (MBI) to discuss exciting developments and potentially develop collaborations with the long-term goal of developing a joint PhD program. The symposium is a two day event, held on the 18th and 19th of November, 2013, involving seven PIs from Manchester and thirteen PIs from MBI, as well as one invited guest from UCSD.

The symposium is organized by the Mechanobiology Institute, Singapore, and will be held at the T-Lab Building, National University of Singapore, to include scientific oral presentations and poster sessions as well as social events for networking between invited and local speakers. The Manchester guests will also be given a tour of MBI facilities and there will be ample time for one-on-one meetings between PIs to discuss possible collaborations. There will be 22 talks (30 min duration) and a discussion of future directions at the end of the meeting.


Day 1
November 18, 2013
8:15 Registration
8:45-9:00 Welcoming notes – Mike Sheetz, Charles Streuli
Morning session I
Christoph Ballestrem, chair
9:00-9:30 Mike Sheetz (MBI) – Local contractions for rigidity sensing
9:30-10:00 Charles Streuli (Manchester) – Novel roles for mechanotransduction in normal breast biology
10:00-10:30 Wu Min (MBI) – Plasticity of the endocytic machinery
10:30-11:00 Tea break
Morning session I, continued
Alexander Bershadsky, chair
11:00-11:30 Ronen Zaidel-Bar (MBI) – Non-canonical role of E-cadherin in C. elegans cytokinesis
11:30-12:00 Christoph Ballestrem (Manchester) – Sensing at different interfaces: from focal adhesions to microtubules
12:00-12:30 Mohan Balasubramanian (MBI) – Cytokinesis in vitro
12:30-13:00 Rachel Lennon (Manchester) – How is force regulated in the glomerular podocyte?
13:00-15:30 Lunch + poster session
Afternoon session I
Charles Steuli, chair
15:30-16:00 GV Shivashankar (MBI) – Nuclear mechanics and genome regulation
16:00-16:30 Karl Kadler (Manchester) – Molecular analysis of the biomechanical interface between cells and extracellular matrix
16:30-17:00 Low Boon Chuan (MBI) – Integrin-specific activation of Rho/ROCK/Myosin by a GTPase scaffold
17:00-17:30 Herbert Schiller (Max Planck) – Proteomic profiling of ECM and protein secretion in lung injury reveals modulators of pulmonary compliance
17:30-18:00 Dorit Hanein (Sanford Burnham Institute) Viewing in 3D the molecular architecture of matrix adhesion machinery in situ; One Assembly at a Time
18:00-18:30 Tour of MBI labs and facilities
18:30 Bus to hotel
Day 2
November 19, 2013
Morning session II
Andreas Prokop, chair
9:00-9:30 Alexander Bershadsky (MBI) – Contractility driven self-organization of the actin cytoskeleton
9:30-10:00 Andrew Gilmore (Manchester) – ECM dependent regulation of programmed cell death
10:00-10:30 Virgile Viasnoff (MBI) – Biomimetic interfaces to control cell polarization
10:30-11:00 Tea break
Morning session II, continued
Ronen Zaidel-Bar, chair
11:00-11:30 Nils Gauthier (MBI) – Membrane tension: a physical signal that orchestrates cell functions
11:30-12:00 Ray Boot-Handford (Manchester) – Stress and loss of rhythms induced by a mechanically-stimulated form of osteoarthritis in the mouse
12:00-12:30 Fumio Motegi (MBI) – Heads or tails: partitioning of cell cortex in C. elegans zygotes
12:30-13:00 Jay Groves (MBI, UC-Berkley) – Mechanics of signal transduction in cell membranes at the single molecule level
13:00-15:30 Lunch + poster session
Afternoon session II
GV Shivashankar, chair
15:30-16:00 Andreas Prokop (Manchester) – Using Drosophila genetics to decipher  force-dependent regulation of axon growth
16:00-16:30 Yusuke Toyama (MBI) – Regulation of mechanical forces, cell-cell and cell-matrix adhesion during apoptosis
16:30-17:00 Tony Pakorn Kanchanawong (MBI) – Role of talin in determination of the nanoscale architecture of focal adhesions
17:00-17:30 Andrew Chisholm (UCSD) – Cellular repair and wound healing in C. elegans
17:30-17:45 Concluding remarks
18:00-19:30 Social sightseeing (conference speakers only)
19:30- Symposium dinner (conference speakers only)

Download symposium schedule [PDF]



cell matrix research logoWellcome Trust Centre for Cell-Matrix Research

Cell-matrix research is all about how cells interact with their local microenvironment. These interactions are necessary both to control how cells actually behave and to build tissues, which are complex collections of many cell types. In our work, we are determining the molecular events that determine how cells and matrix work together.

The work carried out within the Cell-Matrix Centre focuses on addressing these essential biological questions. By connecting with clinical scientists, we ultimately aim to translate our laboratory discoveries to improving diagnosis and treating medically important diseases both of western nations and the developing world.

The Cell-Matrix Centre consists of 20 research teams. Our basic biology research is conducted by around 40 postdoctoral fellows and 50 PhD students, and is supported by about 20 technicians and support staff. Altogether the Centre is a large and productive international research group of around 130 scientists.

Find out more about the Wellcome Trust Centre for Cell-Matrix Research.

mbi logo

The Mechanobiology Institute, Singapore (MBI)

The MBI, headed by Prof Michael Sheetz,  was established in 2009, through joint funding by the National Research Foundation and the Ministry of Education of Singapore, with the goal of creating a new cutting edge research center focusing on diverse aspects of mechanobiology. The primary goal of the MBI is to identify, measure and describe the roles of forces in driving cell motility and morphogenesis, and characterize the mechanisms underlying these processes at the molecular, cellular and tissue levels. Toward that goal, the MBI working to create a common international standard for defining these steps by developing powerful new computational models, experimental reagents, and tools for studying cells and tissues, either healthy or diseased. These ambitious objectives are addressed by interdisciplinary teams drawn from Singapore and international researchers in medicine, biology, chemistry, physics, engineering and computing. Learn more about MBI.