Principal Investigator, MBI
email: hogue@nus.edu.sg
Associate Professor, Department of Biological Sciences, National University of Singapore Associate Professor, Department of Biochemistry, University of Toronto Scientist, Samuel Lunenfeld Research Institute, Toronto
RESEARCH AREAS
Bioinformatics, protein folding, mechanisms of mechanobiological processes and molecular animation. Biophysical characterisation of nonglobular proteins and modeling of statistical ensemble structures of proteins. Determining order of events in molecular assembly and evolution.
RESEARCH INTERESTS
We are interested in a systems approach to understand the basis of mechanobiological function at the molecular level. We use both bioinformatics and experimental techniques focusing on purified molecular systems involving proteins and RNA and biophysical techniques like mass spectrometry, intrinsic fluorescence and FRET. We are studying a variety of systems including the mechanical relationship between ATPases and hexameric helicases, the mechanical origin of ribosomal protein synthesis, and the mechanical transitions that may be present in a defined class of protein domains we call ‘scaffold-style domains’. We have patented software (TraDES) that is used to sample these ensemble conformational states. My group is also responsible for delivery of the RCE in Mechanobiology effort to construct an online resource of information known as MBInfo which can be found at mechanobio.info.
BIOGRAPHY
Dr Hogue is a founding full-time member of MBI and supports the computational biology infrastructure of the group. Formerly at the University of Toronto, Dr Hogue was the Principal Investigator who developed the Biomolecular Interaction Network Database. BIND is recognised as the first and most complete molecular interaction database of its kind. The intellectual property behind his research – including BIND and over a million lines of source code – was acquired by Thomson Scientific, making him the first grant recipient to successfully commercialise research work resulting from a Genome Canada investment. A self-taught software developer and architect, he did his Postdoctoral training at NCBI. Highly cited with over 50 peer reviewed papers and over 5000 citations, he has an ongoing academic interest in computational and wet-lab research.
SELECTED PUBLICATIONS
Betel D, Breitkreuz KE, Isserlin R, Dewar-Darch D, Tyers M, and Hogue CWV. Structure-templated predictions of novel protein interactions from sequence information. PLOS Computational Biology 2007 3:1783-9.
Snyder, K.A. Feldman, H.J., Dumontier, M., Salama J.J., and Hogue CWV. Domain-based Small Molecule Binding Site Annotation. BMC Bioinformatics. 2006 7:152.
Alfarano C, et al, and Hogue CW. 2005. The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Research. 33(Database Issue):D418-D424.
Portet, S., Tuszynski, J.A., Hogue, C.W.V., Dixon, J.M. Elastic vibrations in seamless microtubules. The European Biophysics Journal. 2005. In Press. PMID:15886985
Feldman, H.J., and Hogue, C.W.V. (2000) A fast method to sample real protein conformational space. Proteins 39:112-131.
