Research at the MBI

At the Mechanobiology Institute we are exploring the effects of structural micro-environments and force-induced deformations on molecules, cells and tissues in several different contexts, including the differentiation of stem cells and cancer cell pathology. The field of mechanobiology arose from the cross-roads of multiple disciplines including; cell and molecular biology, engineering, physics and computer science. New technologies such as high resolution time-lapse microscopy and micro-scale devices have vastly enhanced the study of mechanobiology, by enabling the description of complex functions at the sub-micrometer level. Learn more about research at the MBI.

Latest publications

3D Protein Dynamics in the Cell Nucleus. BIOPHYSICAL JOURNAL, January 2017

By Sruthi Jagannathan | Published January 10th, 2017

By Anand P. Singh1, Remi Galland2,3, Megan L. Finch-Edmondson1,4, Gianluca Grenci1, Jean-Baptiste Sibarita2,3, Vincent Studer2,3, Virgile Viasnoff1,5,6, and Timothy E. Saunders1,5,7 Biophysical Journal. January 2017. 112(1). 133-142. doi: Abstract   The three-dimensional (3D) architecture of the cell nucleus plays an important role in protein dynamics and in regulating gene expression. However, protein dynamics within the 3D…

Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. The Journal of Cell Biology, January 2017

By Sruthi Jagannathan | Published January 2nd, 2017

By Nisha Bte Mohd Rafiq1,2,3, Zi Zhao Lieu1,2, Tingting Jiang1, Cheng-han Yu1, Paul Matsudaira1,2, Gareth E. Jones3, Alexander D. Bershadsky1,4 The Journal of Cell Biology. January 2017. 216(1). 181-197. doi: 10.1083/jcb.201605104 Abstract Podosomes represent a class of integrin-mediated cell-matrix adhesions formed by migrating and matrix-degrading cells. We demonstrate that in macrophage-like THP1 cells and fibroblasts stimulated to…

Nanoscale architecture of cadherin-based cell adhesions. Nature Cell Biology, December 2016

By Sruthi Jagannathan | Published December 19th, 2016

By Cristina Bertocchi1, Yilin Wang1, Andrea Ravasio1, Yusuke Hara1, Yao Wu1, Talgat Sailov1, Michelle A. Baird2, Michael W. Davidson2,3, Ronen Zaidel-Bar1,4, Yusuke Toyama1,5,6, Benoit Ladoux1,7, Rene-Marc Mege7 & Pakorn Kanchanawong1,4 Nature Cell Biology. December 2016. 19(1). 28-37. doi: 10.1038/ncb3456. Abstract Multicellularity in animals requires dynamic maintenance of cell-cell contacts. Intercellularly ligated cadherins recruit numerous proteins to form…

Coordination between intra- and extra- cellular forces regulates focal adhesion dynamics. NANO LETTERS, December 2016.

By Sruthi Jagannathan | Published December 19th, 2016

By Bibhu Ranjan Sarangi, Mukund Gupta, Bryant L Doss, Nicolas Tissot, France Lam, René Marc Mege, Nicolas Borghi, and Benoit Ladoux Nano Letters. December 2016. Epub ahead of print. doi: 10.1021/acs.nanolett.6b04364 Abstract Focal adhesions (FAs) are important mediators of cell-substrate interactions. One of their key functions is the transmission of forces between the intracellular acto-myosin network and…

Non-junctional E-Cadherin Clusters Regulate the Actomyosin Cortex in the C. elegans Zygote. Current Biology, December 2016.

By Sruthi Jagannathan | Published December 15th, 2016

By Anup Padmanabhan1, Hui Ting Ong1, Ronen Zaidel-Bar2 Current Biology. December 2016. Epub ahead of print. doi: 10.1016/j.cub.2016.10.032. Abstract Classical cadherins are well known for their essential function in mediating cell-cell adhesion via their extra-cellular cadherin domains and intra-cellular connections to the actin cytoskeleton [1-3]. There is evidence, however, of adhesion-independent cadherin clusters existing outside of cell-cell…

Remodeling of adhesion and modulation of mechanical tensile forces during apoptosis in Drosophila epithelium. Development, November 2016

By Sruthi Jagannathan | Published November 25th, 2016

By Xiang Teng1,2, Lei Qin2, Roland Le Borgne3,4, Yusuke Toyama5,2,6 Development. November 2016. 144(1). 95-105. doi: 10.1242/dev.139865. Abstract Apoptosis is a mechanism of eliminating damaged or unnecessary cells during development and tissue homeostasis. During apoptosis within a tissue, the adhesions between dying and neighboring non-dying cells need to be remodeled so that the apoptotic cell is expelled….

Extracting Microtubule Networks from Superresolution Single-Molecule Localization Microscopy Data. Molecular Biology of the Cell, November 2016

By Sruthi Jagannathan | Published November 10th, 2016

By Zhen Zhang1, Yukako Nishimura1, and Pakorn Kanchanawong2,3 Molecular Biology of the Cell. November 2016. 28(2). 333-345. doi: 10.1091/mbc.E16-06-0421. Abstract Microtubule filaments form ubiquitous networks that specify spatial organization in cells. However, quantitative analysis of the microtubule networks is hampered by their complex architecture, limiting insights into the interplay between their organization and cellular functions. Although superresolution…

Emergence of microfluidic wearable technologies. Lab on a Chip, 2016.

By Sruthi Jagannathan | Published September 28th, 2016

By Joo Chuan Yeo1, Kenry1 and Chwee Teck Lim2 Lab on a Chip. September 2016. Epub ahead of print. Abstract There has been an intense interest in the development of wearable technologies, arising from increasing demands in the areas of fitness and healthcare. While still at an early stage, incorporating microfluidics in wearable technologies has enormous…

To ∼P or Not to ∼P? Non-canonical Activation by Two-Component Response Regulators. Molecular Microbiology, 2016.

By Sruthi Jagannathan | Published September 22nd, 2016

By Stuti K Desai1, Linda J Kenney2,3,4. Molecular Microbiology. September 2016. doi: 10.1111/mmi.13532. Epub ahead of print. Abstract Bacteria sense and respond to their environment through the use of two-component regulatory systems. The ability to adapt to a wide range of environmental stresses is directly related to the number of two-component systems an organism possesses. Recent advances…

A Reversible Association between Smc Coiled Coils Is Regulated by Lysine Acetylation and Is Required for Cohesin Association with the DNA. Molecular Cell, 2016.

By Sruthi Jagannathan | Published September 15th, 2016

By Irina Kulemzina1, Keven Ang2, Xiaodan Zhao3, Jun-Thing Teh2, Vikash Verma4, Sasikala Suranthran2, Alap P. Chavda2, Roland G. Huber2, Birgit Eisenhaber2, Frank Eisenhaber5, Jie Yan6, Dmitri Ivanov7.  Molecular Cell. September 2016. 63(6). 1044-1054. doi: 10.1016/j.molcel.2016.08.008. Abstract Cohesin is a ring-shaped protein complex that is capable of embracing DNA. Most of the ring circumference is comprised of the…