About the National University of Singapore

About NUSA leading global university centred in Asia, NUS is Singapore's flagship university, offering a global approach to education and research with a focus on Asian perspectives and expertise.

About the Mechanobiology Institute, National University of Singapore

About MBIOne of four Research Centres of Excellence at NUS, MBI is working to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.
Benoit Ladoux 2017-05-03T10:53:20+00:00
Benoit LADOUX

Benoit LADOUX

Co-Principal Investigator, Mechanobiology Institute, National University of Singapore

benoit.ladoux@ijm.fr
+3301 57 27 80 71
Institut Jacques Monod
Batiment Buffon – Université Paris 7
10 rue Hélène Brion
75205 Paris cedex 13, France

Laboratory website
Cell Adhesion and Mechanics Lab

Research Program
Mechanotransduction in Tissues Group

Affiliations
Professor, Institut Jacques Monod, UMR 7592 CNRS and University Paris Diderot

Recent Research

Illuminating the Contacts

Using superresolution imagining to map adherens junction machinery

By | Feb 10th, 2017|Categories: Bertocchi Research, Featured Research, Hara Research, Kanchanawong Lab, Ladoux Lab, Ravasio Research, Science Features, Toyama Lab, Zaidel-Bar Lab|Comments Off on Illuminating the Contacts

Cell Extrusion Mechanisms

Making sure to expel an unwanted cell

By | Oct 20th, 2016|Categories: Featured Research, Ladoux Lab, Le AP Research, Lim CT Lab, Saw TB Research, Science Features, Shagirov M Research, Toyama Lab, Yow I Research|Comments Off on Cell Extrusion Mechanisms

Benoit Ladoux

Co-Principal Investigator

Research Areas

Epithelial cell migration; microfabrication for cell mechanics; influence of the mechanical environments on cell functions; mechanotransduction

Research Interests

Our research aims at understanding how living organisms interact with their environment. In particular, we are studying the cooperation between adhesion, biomechanical and biochemical signaling for the adaptation of living organisms to changes in their environment. To probe these questions, our laboratory has developed a repertoire of micro- and nano-fabrication tools to control and measure the chemical and mechanical environment of cells. Our research programme thus focuses on the integration of novel microfabricated devices for the quantitative imaging of living organisms.

Biography

With a background in Physics, Prof Ladoux started his career at Curie Institute working on single molecule biophysics. He worked on two main problems combining statistical physics, microfabrication and molecular biology: 1) chromatin condensation in real time; 2) fluctuations of a single polymer under shear flows. After a post-doc on cell mechanics, he used his knowledge in biophysics and microfabrication to start a new subject on mechanical studies of cell migration and adhesion at the University Paris Diderot. He developed microsystems to characterise the mechanical interactions of cells with their migration support. He is currently working on rigidity sensing, collective cell migration and tissue homeostasis.

Recent Publications

  1. Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, Toyama Y, Marcq P, Lim CT, Yeomans JM, and Ladoux B. Topological defects in epithelia govern cell death and extrusion. Nature 2017; 544(7649):212-216. [PMID: 28406198]
  2. Salomon J, Gaston C, Magescas J, Duvauchelle B, Canioni D, Sengmanivong L, Mayeux A, Michaux G, Campeotto F, Lemale J, Viala J, Poirier F, Minc N, Schmitz J, Brousse N, Ladoux B, Goulet O, and Delacour D. Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity. Nat Commun 2017; 8:13998. [PMID: 28084299]
  3. Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege R, and Kanchanawong P. Nanoscale architecture of cadherin-based cell adhesions. Nat. Cell Biol. 2016;. [PMID: 27992406]
  4. Sarangi BR, Gupta M, Doss BL, Tissot N, Lam F, Mège R, Borghi N, and Ladoux B. Coordination between Intra- and Extracellular Forces Regulates Focal Adhesion Dynamics. Nano Lett. 2016;. [PMID: 27990827]
  5. Hirata H, Gupta M, Vedula SRK, Lim CT, Ladoux B, and Sokabe M. Quantifying Tensile Force and ERK Phosphorylation on Actin Stress Fibers. Methods Mol. Biol. 2017; 1487:223-234. [PMID: 27924570]
  6. Kocgozlu L, Saw TB, Le AP, Yow I, Shagirov M, Wong E, Mège R, Lim CT, Toyama Y, and Ladoux B. Epithelial Cell Packing Induces Distinct Modes of Cell Extrusions. Curr. Biol. 2016;. [PMID: 27746027]
  7. Begnaud S, Chen T, Delacour D, Mège R, and Ladoux B. Mechanics of epithelial tissues during gap closure. Curr. Opin. Cell Biol. 2016; 42:52-62. [PMID: 27131272]
  8. Choi W, Acharya BR, Peyret G, Fardin M, Mège R, Ladoux B, Yap AS, Fanning AS, and Peifer M. Remodeling the zonula adherens in response to tension and the role of afadin in this response. J. Cell Biol. 2016; 213(2):243-60. [PMID: 27114502]
  9. Nier V, Jain S, Lim CT, Ishihara S, Ladoux B, and Marcq P. Inference of Internal Stress in a Cell Monolayer. Biophys. J. 2016; 110(7):1625-35. [PMID: 27074687]
  10. Gupta M, Doss B, Lim CT, Voituriez R, and Ladoux B. Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling. Cell Adh Migr 2016;:1-14. [PMID: 27050660]

Lab Members

Saw Thuan Beng

Apr 25th, 2017|Comments Off on Saw Thuan Beng

PhD Student, Lim Group, Ladoux Group

Le Anh Phuong

Apr 25th, 2017|Comments Off on Le Anh Phuong

PhD Student, Ladoux Group, Lim Group

Shreyansh Jain

Apr 13th, 2017|Comments Off on Shreyansh Jain

PhD Student, Lim Group, Ladoux Group

Pan Meng

Apr 11th, 2017|Comments Off on Pan Meng

Research Associate, Ladoux Group

Chen Tianchi

Apr 11th, 2017|Comments Off on Chen Tianchi

PhD Student, Ladoux Group

Hayri Emrah Balcioglu

Apr 11th, 2017|Comments Off on Hayri Emrah Balcioglu

Research Fellow, Ladoux Group

Bryant Lee Doss

Apr 11th, 2017|Comments Off on Bryant Lee Doss

Research Fellow, Ladoux Group