Our vision: to create the world’s leading institute in mechanobiology with a strong and cohesive interdisciplinary team.


MBI is located within NUS’s new university-level research institute, the Temasek Laboratories (T-lab), on the campus of the National University of Singapore.

Instituted in 2009, the Mechanobiology Institute was created through joint funding by the National Research Foundation and the Ministry of Education with the goal of creating a new research centre in mechanobiology to benefit both the discipline and Singapore.

MBI’s primary focus is to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level. Toward that goal, we are working to create a common international standard for defining these steps by developing powerful new computational models, experimental reagents, and tools for studying diseases of cells and tissues. Our goal is then to transfer these basic discoveries to both the clinic and the classroom.

With a systems-level perspective, we are creating MBInfo, a step-by-step, modular understanding of cell mechanics across molecular, cellular and tissue levels. By studying functions in normal and diseased tissues, the Institute will facilitate transfer of our discoveries to medical professionals through a Tissue Repair Manual. The deliverable of this integrated Manual of Cellular and Molecular Function will be accomplished through interdisciplinary teams drawn from Singapore and international researchers in medicine, biology, chemistry, physics, engineering and computing.

Mechanobiology is an emerging discipline, one that demands dedication and researchers with both a broad vision and the drive to succeed. Here at MBI we are creating a new and powerful community of motivated scientists committed to the advancement of the discipline and the future of mechanobiology.

Our mission

At the Mechanobiology Institute, Singapore, our goal is to develop a new paradigm of biomedical research by focusing on the quantitative and systematic understanding of dynamic functional processes. Read more about MBI’s Mission.

A message from MBI’s director

“From bacteria to humans, mechanics is critical to our understanding of cell and tissue function.  How cells are shaped, how they move, how their growth is controlled, and how they form larger tissues are fundamental questions that are biomechanical.  With a deeper understanding of the mechanical functions that underlie many processes from cancer to aging, new paradigms can be developed to treat diseases and facilitate tissue regeneration. —excerpt from Director Sheetz’s message. Read more.

Contact us

MBI is located on the campuses of the National University of Singapore. We welcome your questions about our mission and our site.  Contact us.