How dying cells detach and are expelled from a tissue, and how tissue tension in the region surrounding a dying cell is remodeled.
Illuminating the Contacts
With super-resolution microscopy at their disposal, an international research team led by Asst. Prof. Pakorn (Tony) Kanchanawong have revealed, for the first time, how the cadherin-based cell-cell contacts are organized.
Research from the Bershadsky Lab has revealed that a protein known as Arf1 plays a role in podosome formation by regulating the assembly of myosin-II within the cytoskeleton.
Stability Without Junctions
Cadherin prevents cortical deformation
Cell Extrusion Mechanisms
Cell density regulates how cells are removed from the epithelial cell sheet.
A moving story of FHL2 and Forces
How FHL2 translocates to the nucleus under low tension