Vinculin Anchors Actin Cytoskeleton to Focal Adhesions

Prof Yan shows that stretching forces applied to living cells increase vinculin accumulation at talin-containing focal adhesions thus anchoring the actin cytoskeleton.

The Influence of Nanotopography on Stem Cell Differentiation

Prof Yim highlights an important role of FAK in the mechano- transduction and differentiation of stem cells.

P53 in the Fight Against Cancer Cell Invasion

Kawauchi lab reveals how p53 suppresses Ras-mediated cell invasion through activation of HtrA2/Omi and a subsequent modulation of the actin cytoskeleton.

Podosome formation requires no cell-matrix traction force

MBI’s Cheng-han Yu from the Sheetz group has shown that in the absence of traction forces, for example, on fluid substrates, fibroblasts form podosomes rather than focal adhesions.

Slowing down liver cancer

MBI PI Low Boon Chuan’s lab has found switching on the Rho protein slows the growth of liver tumours by up to 30 percent.

A breakthrough in wound healing

Profs Lim and Ladoux have discovered how keratinocytes form “bridges” across damaged skin, even in areas devoid of a supporting extracellular matrix.